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pentobarbital will lessen the extent or impact of propafenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unidentified.pentobarbital will reduce the extent or outcome of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3